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How Varithena Works

Varithena is an injectable foam composed of a liquid phase and a gas phase, both of which are necessary for therapeutic effect.

A Powerful Foam Designed for Consistent Performance

Varithena is a reliable alternative to traditional modalities. The small, low-nitrogen residual bubbles are rapidly absorbed and able to deliver dependable results with reduced complications.

The patented microfoam-generating device produces cohesive, low-nitrogen microfoam.

  • O2:CO2 (65:35) gas mixture with <0.8% nitrogen
  • Reliably small bubbles (median diameter <100 µm; all ≤500 µm)
  • 7:1 gas: liquid ratio enhances blood displacement to allow for longer dwell time in the vessel.
Not Just Another Foam image

Not Just Another Foam

Varithena is the only specially formulated microfoam with patented technology that results in a uniform density, size and stability (UDSS™) microfoam, so it’s longer lasting and slower to break down.

Straightforward Treatment Steps

See How the Treatment Works

This short, animated video shows you how Varithena treatment affects diseased veins once the microfoam is injected.

  1.   Incompetent tributaries can be treated through either one injection site, or when warranted, multiple injection sites.
  2.   A column of microfoam advances to fill the vein.
  3.   Varithena displaces blood, effectively filling the lumen for circumferential contact.1
  4.   Varithena achieves endothelial destruction with very low polidocanol concentration.
  5.   The vein contracts, narrowing the lumen until vein has almost no volume.
  6.   Residual, low-nitrogen bubbles are highly absorbable in blood and are swept away and absorbed in venous circulation.1

Have questions?

See How the Microfoam is Generated

This video explains how the canister device is activated to dispense cohesive, low nitrogen microfoam.

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  1. Eckmann DM. Polidcanol for endovenous microfoam sciarsant therapy. Expert Opin Investing Drugs. 2009: 18(12) 1919-1927.


Varithena® (polidocanol injectable foam) is indicated for the treatment of incompetent great saphenous veins,  accessory saphenous veins and visible varicosities of the great saphenous vein (GSV) system above and below the knee. Varithena® improves the symptoms of superficial venous incompetence and the appearance of visible varicosities.

Important Safety Information

The use of Varithena® is contraindicated in patients with known allergy to polidocanol and those with acute thromboembolic disease. Severe allergic reactions have been reported following administration of liquid polidocanol, including anaphylactic reactions, some of them fatal. Observe patients for at least 10 minutes following injection and be prepared to treat anaphylaxis appropriately. Intra-arterial injection or extravasation of polidocanol can cause severe necrosis, ischemia or gangrene. Patients with underlying arterial disease may be at increased risk for tissue ischemia. If intra-arterial injection of polidocanol occurs, consult a vascular surgeon immediately.Varithena® can cause venous thrombosis. Follow administration instructions closely and monitor for signs of venous thrombosis after treatment. Patients with reduced mobility, history of deep vein thrombosis or pulmonary embolism, or recent (within 3 months) major surgery, prolonged hospitalization, or pregnancy are at increased risk for developing thrombosis. The most common adverse events observed were pain/discomfort in extremity, retained coagulum, injection site hematoma or pain, common femoral vein thrombus extension, superficial thrombophlebitis, and deep vein thrombosis.Physicians administering Varithena® must be experienced with venous procedures, possess a detailed working knowledge of the use of the duplex ultrasound in venous disease and be trained in the administration of Varithena®.

See Full Prescribing Information for Varithena®